In vitro inhibition properties of a new group of thiobenzanilides in relation to yeasts

The antifungal potency of a series of 2,4-dihydroxythiobenzanilides was tested. MIC assessments were used for the estimation of potential activity in vitro against Candida, Cryptococcus, Geotrichum and Trichosporon species. The strongest fungistatic activity was observed for dichloro derivatives (MIC 7.82-31.21 mu g/ml). The action of these compounds depends on lipophilicity, determined by the substitution of N-aryl moiety and the electron properties of molecules. The lipophilicity, expressed by R-Mw values, was determined in the reversed-phase system. The changes in the nature of the thioamide bond were interpreted on the basis of UV and H-1 NMR spectra. (C) 2000 Elsevier Science B.V. All rights reserved.