Associating Emergency Medical Services personnel's workload, trauma exposure, and health with the cortisol, endocannabinoid, and N-acylethanolamine concentrations in their hair

被引:17
作者
Behnke, Alexander [1 ]
Karabatsiakis, Alexander [1 ,2 ]
Krumbholz, Aniko [3 ]
Karrasch, Sarah [1 ]
Schelling, Gustav [4 ]
Kolassa, Iris-Tatjana [1 ]
Rojas, Roberto [5 ]
机构
[1] Ulm Univ, Inst Psychol & Educ, Clin & Biol Psychol, D-89081 Ulm, Germany
[2] Univ Innsbruck, Inst Psychol, A-6020 Innsbruck, Austria
[3] Inst Doping Anal & Sports Biochem IDAS Dresden, D-01731 Kreischa, Germany
[4] Ludwig Maximilians Univ Munchen, Dept Anaesthesiol, D-82131 Munich, Germany
[5] Ulm Univ, Inst Psychol & Educ, Univ Psychotherapeut Outpatient Clin, D-89073 Ulm, Germany
关键词
POSTTRAUMATIC-STRESS-DISORDER; CHILDHOOD MALTREATMENT; PSYCHOLOGICAL STRESS; HUMANS; PTSD; INTERVENTION; METAANALYSIS; ADOLESCENTS; OBESITY; LEVEL;
D O I
10.1038/s41598-020-79859-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In their line of duty, Emergency Medical Services (EMS) personnel are exposed to chronically stressful working conditions and recurrent traumatic events, which increase their risk for detrimental health outcomes. Here, we investigated whether this risk is due to altered regulation of the hypothalamus-pituitary-adrenal (HPA) axis and the endocannabinoid system. Therefore, 1 cm hair strands were collected from a cohort of 72 German EMS personnel in order to measure concentrations of cortisol, endocannabinoids [i.e., anandamide (AEA), 2-arachidonoylglycerol (2-AG)], and N-acylethanolamines [i.e., stearoylethanolamide (SEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA)]. Rank correlation analyses were conducted to test associations of cortisol, endocannabinoid, and N-acylethanolamine concentrations with the EMS personnel's workload, lifetime trauma exposure, and mental and physical health problems. We found a negative correlation between cortisol and 2-AG concentrations in hair. Higher hair cortisol was associated with higher workload. Reported traumatic stress during childhood and later in life as well as more severe depressive and physical stress symptoms were associated with elevated 2-AG, SEA, OEA, and PEA concentrations. Future longitudinal research needs to address the prospect of tracing biomolecular markers of glucocorticoid, endocannabinoid, and N-acylethanolamine activity as a predicting value of the long-term course of mental and physical well-being.
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页数:10
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