19F applications in drug development and imaging - a review

被引：14

作者：

Bartusik, Dorota ^{[1
]}

Aebisher, David ^{[2
]}

机构：

[1] Southern Polytech State Univ, Dept Biol & Chem, Marietta, GA 30060 USA

[2] Shorter Univ, Dept Nat Sci, Rome, GA 30165 USA

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2014年 / 68卷 / 06期

关键词：

F-19; drugs; MRI; CATALYTIC ENANTIOSELECTIVE FLUORINATION; ELECTROPHILIC FLUORINATION; IN-VIVO; ASYMMETRIC-SYNTHESIS; MEDICINAL CHEMISTRY; ELEMENTAL FLUORINE; FLUOROXY-COMPOUNDS; PERFLUOROCARBON; ALPHA; BIODISTRIBUTION;

D O I：

10.1016/j.biopha.2014.07.012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To control drugs in vivo, new approaches are needed. Considerable progress has been made towards the applications of fluorine (F-19) in pharmacotherapy in this regard. To date, many authors have showed that by using F-19 labelled drugs and non-invasive magnetic resonance imaging (MRI) techniques together, drug biodistribution can be tracked. This review presents methods for F-19 incorporation into pharmaceuticals by forming C-F bonds and drug fluorine oil-water emulsions. Inadequate drug delivery is a major cause of drug resistance, which can be improved using approaches discussed herein aided by F-19 MRI. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：813 / 817

页数：5

共 50 条

[21] 19F Oximetry with semifluorinated alkanes [J].

Kegel, Stefan ;

Chacon-Caldera, Jorge ;

Tsagogiorgas, Charalambos ;

Theisinger, Bastian ;

Glatting, Gerhard ;

Schad, Lothar R. .

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2016, 44 (08) :1861-1866

[22] 19F CEST imaging probes for metal ion detection [J].

Peng, Qiaoli ;

Yuan, Yaping ;

Zhang, Huaibin ;

Bo, Shaowei ;

Li, Yu ;

Chen, Shizhen ;

Yang, Zhigang ;

Zhou, Xin ;

Jiang, Zhong-Xing .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 15 (30) :6441-6446

[23] Simultaneous Dual-Nuclei Imaging for Motion Corrected Detection and Quantification of 19F Imaging Agents [J].

Keupp, Jochen ;

Rahmer, Juergen ;

Graesslin, Ingmar ;

Mazurkewitz, Peter C. ;

Schaeffter, Tobias ;

Lanza, Gregory M. ;

Wickline, Samuel A. ;

Caruthers, Shelton D. .

MAGNETIC RESONANCE IN MEDICINE, 2011, 66 (04) :1116-1122

[24] 19F magnetic resonance imaging of endogenous macrophages in inflammation [J].

Temme, Sebastian ;

Boenner, Florian ;

Schrader, Juergen ;

Floegel, Ulrich .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2012, 4 (03) :329-343

[25] Hot spot 19F magnetic resonance imaging of inflammation [J].

Bouvain, Pascal ;

Temme, Sebastian ;

Floegel, Ulrich .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2020, 12 (06)

[26] Fluorinated Polyurethane Scaffolds for 19F Magnetic Resonance Imaging [J].

Lammers, Twan ;

Mertens, Marianne E. ;

Schuster, Philipp ;

Rahimi, Khosrow ;

Shi, Yang ;

Schulz, Volkmar ;

Kuehne, Alexander J. C. ;

Jockenhoevel, Stefan ;

Kiessling, Fabian .

CHEMISTRY OF MATERIALS, 2017, 29 (07) :2669-2671

[27] Lanthanide Complexes with 1H paraCEST and 19F Response for Magnetic Resonance Imaging Applications [J].

Pujales-Paradela, Rosa ;

Savic, Tanja ;

Perez-Lourido, Paulo ;

Esteban-Gomez, David ;

Angelovski, Goran ;

Botta, Mauro ;

Platas-Iglesias, Carlos .

INORGANIC CHEMISTRY, 2019, 58 (11) :7571-7583

[28] In vivo 19F MR imaging and spectroscopy for the BNCT optimization [J].

Porcari, P. ;

Capuani, S. ;

D'Amore, E. ;

Lecce, M. ;

La Bella, A. ;

Fasano, F. ;

Migneco, L. M. ;

Campanella, R. ;

Maraviglia, B. ;

Pastore, F. S. .

APPLIED RADIATION AND ISOTOPES, 2009, 67 (7-8) :S365-S368

[29] Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and 19F Magnetic Resonance Imaging [J].

Higashino, Tomohiro ;

Nakatsuji, Hirotaka ;

Fukuda, Ryosuke ;

Okamoto, Haruki ;

Imai, Hirohiko ;

Matsuda, Tetsuya ;

Tochio, Hidehito ;

Shirakawa, Masahiro ;

Tkachenko, Nikolai V. ;

Hashida, Mitsuru ;

Murakami, Tatsuya ;

Imahori, Hiroshi .

CHEMBIOCHEM, 2017, 18 (10) :951-959

[30] Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes [J].

Cho, Mi Hyeon ;

Shin, Soo Hyun ;

Park, Sang Hyun ;

Kadayakkara, Deepak Kana ;

Kim, Daehong ;

Choi, Yongdoo .

BIOCONJUGATE CHEMISTRY, 2019, 30 (10) :2502-2518

← 1 2 3 4 5 →