19F applications in drug development and imaging - a review

被引：14

作者：

Bartusik, Dorota ^{[1
]}

Aebisher, David ^{[2
]}

机构：

[1] Southern Polytech State Univ, Dept Biol & Chem, Marietta, GA 30060 USA

[2] Shorter Univ, Dept Nat Sci, Rome, GA 30165 USA

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2014年 / 68卷 / 06期

关键词：

F-19; drugs; MRI; CATALYTIC ENANTIOSELECTIVE FLUORINATION; ELECTROPHILIC FLUORINATION; IN-VIVO; ASYMMETRIC-SYNTHESIS; MEDICINAL CHEMISTRY; ELEMENTAL FLUORINE; FLUOROXY-COMPOUNDS; PERFLUOROCARBON; ALPHA; BIODISTRIBUTION;

D O I：

10.1016/j.biopha.2014.07.012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To control drugs in vivo, new approaches are needed. Considerable progress has been made towards the applications of fluorine (F-19) in pharmacotherapy in this regard. To date, many authors have showed that by using F-19 labelled drugs and non-invasive magnetic resonance imaging (MRI) techniques together, drug biodistribution can be tracked. This review presents methods for F-19 incorporation into pharmaceuticals by forming C-F bonds and drug fluorine oil-water emulsions. Inadequate drug delivery is a major cause of drug resistance, which can be improved using approaches discussed herein aided by F-19 MRI. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：813 / 817

页数：5

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