Identifying therapeutic targets in gastric cancer: the current status and future direction

被引：17

作者：

Yu, Beiqin ^{[1
,2
,3
,4
]}

Xie, Jingwu ^{[2
,3
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Digest Surg, Shanghai Key Lab Gastr Neoplasms,Ruijin Hosp, Shanghai 200025, Peoples R China

[2] Wells Ctr Pediat Res, Dept Pediat, Indianapolis, IN 46202 USA

[3] Wells Ctr Pediat Res, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[4] Wells Ctr Pediat Res, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2016年 / 48卷 / 01期

关键词：

gastric cancer; targeted therapy; cancer stem cell; Wnt; hedgehog; CHRONIC MYELOID-LEUKEMIA; ABL TYROSINE KINASE; DRUG-RESISTANCE; MOLECULAR-BASIS; STEM-CELLS; MULTIDRUG-RESISTANCE; ACQUIRED-RESISTANCE; ANTICANCER DRUG; MISMATCH REPAIR; BREAST-CANCER;

D O I：

10.1093/abbs/gmv084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is the third leading cause of cancer-related death worldwide. Our basic understanding of gastric cancer biology falls behind that of many other cancer types. Current standard treatment options for gastric cancer have not changed for the last 20 years. Thus, there is an urgent need to establish novel strategies to treat this deadly cancer. Successful clinical trials with Gleevec in CML and gastrointestinal stromal tumors have set up an example for targeted therapy of cancer. In this review, we will summarize major progress in classification, therapeutic options of gastric cancer. We will also discuss molecular mechanisms for drug resistance in gastric cancer. In addition, we will attempt to propose potential future directions in gastric cancer biology and drug targets.

引用

页码：90 / 96

页数：7

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