Short synthetic route toward the tricyclic core of schulzeines

被引：17

作者：

Kuntiyong, Punlop ^{[1
]}

Akkarasamiyo, Sunisa ^{[1
]}

Eksinitkun, Gedsirin ^{[1
]}

机构：

[1] Silpakorn Univ, Fac Sci, Dept Chem, Muang Nakhon Pathom 73000, Thailand

来源：

CHEMISTRY LETTERS | 2006年 / 35卷 / 09期

关键词：

D O I：

10.1246/cl.2006.1008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The tricyclic core of marine natural products schulzeines was synthesized using N-acyliminium ion cyclization. The intermediate N-acyliminium ion was generated from treatment of alpha-hydroxy-delta-lactam with a Lewis acid. The tricyclic products were obtained as a mixture of 2 diastereomers at the C-11b stereocenter. The diastereomeric ratios were low and dependent on the Lewis acid used in the reaction.

引用

页码：1008 / 1009

页数：2

共 5 条

[1] Chiral synthesis of trans-1-aminoindolo[2,3-a] quinolizidine and trans-1-aminobenzo[a]quinolizidine derivatives from L-pyroglutamic acid [J].