The effects of liraglutide on male fertility: a case report

被引:27
作者
Fontoura, Paula [1 ]
de Almeida Cardos, Maria Cecilia [2 ]
Erthal-Martins, Maria Cecilia [2 ]
Werneck, Caio [2 ]
Sartorio, Cassio [2 ]
Ramos, Cristiane Fonte [1 ]
机构
[1] Univ Estado Rio De Janeiro, Dept Anat, BR-22793080 Rio De Janeiro, Brazil
[2] Vida Ctr Fertilidade Clin, BR-22793080 Rio De Janeiro, Brazil
关键词
liraglutide; male infertility; male reproduction; spermatozoa;
D O I
10.1016/j.rbmo.2014.07.009
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Liraglutide is an agonist of the glucagon-like peptide I receptor, and is commonly recommended as a treatment for obesity and type 2 diabetes mellitus. Adverse effects related to liraglutide include acute pancreatitis and polyarthritis. No studies, however, have reported an adverse effect of liraglutide on male reproduction. This case report shows a deleterious effect of liraglutide on male reproductive function. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:644 / 646
页数:3
相关论文
共 9 条
[1]   GLP-1 receptor agonist-induced polyarthritis: a case report [J].
Ambrosio, Maria Luisa ;
Monami, Matteo ;
Sati, Lavinia ;
Marchionni, Niccolo ;
Di Bari, Mauro ;
Mannucci, Edoardo .
ACTA DIABETOLOGICA, 2014, 51 (04) :673-674
[2]  
ASEBIR, 2008, CUAD EMBR CLIN
[3]  
Famularo G, 2012, J PANCREAS, V13, P540, DOI 10.6092/1590-8577/1107
[4]   Sustained Weight Loss After Treatment With a Glucagon-Like Peptide-1 Receptor Agonist in an Obese Patient With Schizophrenia and Type 2 Diabetes [J].
Ishoy, Pelle L. ;
Knop, Filip K. ;
Vilsboll, Tina ;
Glenthoj, Birte Y. ;
Ebdrup, Bjorn H. .
AMERICAN JOURNAL OF PSYCHIATRY, 2013, 170 (06) :681-682
[5]   Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males [J].
Jeibmann, A ;
Zahedi, S ;
Simoni, M ;
Nieschlag, E ;
Byrne, MM .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2005, 35 (09) :565-572
[6]   Liraglutide-associated acute pancreatitis [J].
Knezevich, Emily ;
Crnic, Theresa ;
Kershaw, Scott ;
Drincic, Andjela .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2012, 69 (05) :386-389
[7]   Neuroendocrine function and response to stress mice with complete disruption of glucagon-like peptide-1 receptor signaling [J].
MacLusky, NJ ;
Cook, S ;
Scrocchi, L ;
Shin, J ;
Kim, J ;
Vaccarino, F ;
Asa, SL ;
Drucker, DJ .
ENDOCRINOLOGY, 2000, 141 (02) :752-762
[8]   Glucagon-like peptides I and 2 in health and disease: A review [J].
Marathe, Chinmay S. ;
Rayner, Christopher K. ;
Jones, Karen L. ;
Horowitz, Michael .
PEPTIDES, 2013, 44 :75-86
[9]  
Organization WH, 2010, WHO LAB MAN EX PROC