The key role of mitochondria in Alzheimer's disease

被引：6
作者：
Moreira, P. I.
Cardoso, S. M.
Santos, M. S.
Oliveira, C. R. [1 ]
机构：
[1] Univ Coimbra, Fac Med, Ctr Neurosci & Cell Biol, Inst Physiol, P-3004504 Coimbra, Portugal
[2] Univ Coimbra, Fac Med, Inst Biochem, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal
[3] Univ Coimbra, Fac Sci & Technol, Dept Zool, Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2006年 / 9卷 / 02期
关键词：
Alzheimer's disease; amyloid beta; mitochondria; oxidative stress; apoptosis;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mitochondria are uniquely poised to play a pivotal role in neuronal cell survival or death because they are regulators of both energy metabolism and apoptotic pathways. This review is mainly focused in the discussion of evidence suggesting a clear association between amyloid-beta toxicity, mitochondrial dysfunction, oxidative stress and neuronal damage/death in Alzheimer's disease pathophysiology. The knowledge that mitochondrial dysfunction has a preponderant role in Alzheimer's disease opened a window for new therapeutic strategies aimed to preserve/ameliorate mitochondrial function. Based on recent developments in mitochondrial research, increased pharmacological and pharmaceutical efforts have lead to the emergence of 'Mitochondria) Medicine' as a whole new field of biomedical research being this topic discussed in the last section of this review.
引用
收藏
页码：101 / 110
页数：10
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