Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity

被引：30
作者：
Cocco, MT
Congiu, C
Onnis, V
Morelli, M
Felipo, V
Cauli, O
机构：
[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy
[2] Fdn Valenciana Invest Biomed, Valencia 46010, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 15期
关键词：
D O I：
10.1016/j.bmc.2004.05.025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：4169 / 4177
页数：9
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