Nano-chemotherapeutics: Maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers

被引：115
作者：
Ryan, Gemma M. [1 ]
Kaminskas, Lisa M. [1 ]
Porter, Christopher J. H. [1 ]
机构：
[1] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia
来源：
JOURNAL OF CONTROLLED RELEASE | 2014年 / 193卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Drug delivery systems; Lymphatic; Metastasis; Chemotherapeutic; Lymph node; EFFECTIVELY INHIBITS LYMPHANGIOGENESIS; ACTIVATED CARBON PARTICLES; CHEMOKINE RECEPTOR CCR7; TUMOR-HOMING PEPTIDE; HUMAN-MELANOMA CELLS; PEG CHAIN-LENGTH; BREAST-CANCER; IN-VITRO; NODE METASTASIS; SUBCUTANEOUS INJECTION;
D O I：
10.1016/j.jconrel.2014.04.051
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nano-sized drug delivery systems incorporating chemotherapeutic drugs ("nano-chemotherapeutics") have been widely employed for the treatment of solid tumours. The dimensions of nanoparticulate drug delivery systems also make them ideal vectors for improving drug exposure to the lymphatic system, potentially enhancing the treatment of lymph-resident metastases. This review examines the physical properties of nanoparticulate drug delivery systems that promote lymphatic exposure and lymph node retention, and discusses methods for improving lymphatic access. Drug delivery systems that have been investigated for the treatment of lymph node metastasis are also reviewed, and recent advances towards active targeting approaches for lymphatic metastases highlighted. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：241 / 256
页数：16
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