TGFβ signaling pathways and human diseases

被引：15
|
作者：
Padgett, RW
机构：
[1] Rutgers State Univ, Waksman Inst, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Waksman Inst, Canc Inst New Jersey, Piscataway, NJ 08854 USA
来源：
CANCER AND METASTASIS REVIEWS | 1999年 / 18卷 / 02期
关键词：
TGF beta; Smads; cancer; development; growth factors;
D O I：
10.1023/A:1006325408261
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent progress in deciphering the TGF beta pathway has uncovered a new signaling molecule, the Smads, and with this finding now gives us insights into how TGF beta-like signals are transmitted from outside the cell to the nucleus. As we learn more about how TGF beta regulates normal development, we also are gaining insights into diseases that are caused by mis-regulation or mutation of various components of the signaling pathways.
引用
收藏
页码：247 / 259
页数：13
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