TGFβ signaling pathways and human diseases

被引：15
|
作者：
Padgett, RW
机构：
[1] Rutgers State Univ, Waksman Inst, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Waksman Inst, Canc Inst New Jersey, Piscataway, NJ 08854 USA
来源：
CANCER AND METASTASIS REVIEWS | 1999年 / 18卷 / 02期
关键词：
TGF beta; Smads; cancer; development; growth factors;
D O I：
10.1023/A:1006325408261
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent progress in deciphering the TGF beta pathway has uncovered a new signaling molecule, the Smads, and with this finding now gives us insights into how TGF beta-like signals are transmitted from outside the cell to the nucleus. As we learn more about how TGF beta regulates normal development, we also are gaining insights into diseases that are caused by mis-regulation or mutation of various components of the signaling pathways.
引用
收藏
页码：247 / 259
页数：13
相关论文
共 50 条
  • [1] TGFβ Signaling Pathways and Human Diseases
    Richard W. Padgett
    Cancer and Metastasis Reviews, 1999, 18 : 247 - 259
  • [2] TGFβ signaling pathways in human health and disease
    Chen, Pei-Yu
    Qin, Lingfeng
    Simons, Michael
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2023, 10
  • [3] Pathological roles of MAPK signaling pathways in human diseases
    Kim, Eun Kyung
    Choi, Eui-Ju
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (04): : 396 - 405
  • [4] TGFβ Signaling and Cardiovascular Diseases
    Pardali, Evangelia
    ten Dijke, Peter
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2012, 8 (02): : 195 - 213
  • [5] Alterations in components of the TGF-β superfamily signaling pathways in human cancer
    Levy, L
    Hill, CS
    CYTOKINE & GROWTH FACTOR REVIEWS, 2006, 17 (1-2) : 41 - 58
  • [6] Investigating the Role of TGF-β Signaling Pathways in Human Corneal Endothelial Cell Primary Culture
    Aouimeur, Ines
    Sagnial, Tomy
    Coulomb, Louise
    Maurin, Corantin
    Thomas, Justin
    Forestier, Pierre
    Ninotta, Sandrine
    Perrache, Chantal
    Forest, Fabien
    Gain, Philippe
    Thuret, Gilles
    He, Zhiguo
    CELLS, 2023, 12 (12)
  • [7] TGF-β signaling pathways in cancers
    Talar, Beata
    Czyz, Malgorzata
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2013, 67 : 1008 - 1017
  • [8] PTK-pathways and TGF-β signaling pathways in schistosomes
    Ting-An, Wang
    Hong-Xiang, Zhuge
    JOURNAL OF BASIC MICROBIOLOGY, 2009, 49 (01) : 25 - 31
  • [9] The Role of Endocytic Pathways in TGF-β Signaling
    Balogh, P.
    Katz, S.
    Kiss, A. L.
    PATHOLOGY & ONCOLOGY RESEARCH, 2013, 19 (02) : 141 - 148
  • [10] Schistosoma mansoni:: TGF-β signaling pathways
    LoVerde, Philip T.
    Osman, Ahmed
    Hinck, Andrew
    EXPERIMENTAL PARASITOLOGY, 2007, 117 (03) : 304 - 317
12345