Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

被引：507

作者：

Askew, Katharine ^{[1
]}

Li, Kaizhen ^{[2
]}

Olmos-Alonso, Adrian ^{[1
]}

Garcia-Moreno, Fernando ^{[3
]}

Liang, Yajie ^{[2
]}

Richardson, Philippa ^{[1
]}

Tipton, Tom ^{[4
]}

Chapman, Mark A. ^{[1
]}

Riecken, Kristoffer ^{[5
]}

Beccari, Sol ^{[6
]}

Sierra, Amanda ^{[6
]}

Molnar, Zoltan ^{[3
]}

Cragg, Mark S. ^{[4
]}

Garaschuk, Olga ^{[2
]}

Perry, V. Hugh ^{[1
]}

Gomez-Nicola, Diego ^{[1
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, Biol Sci, Southampton SO16 6YD, Hants, England

[2] Univ Tubingen, Inst Physiol 2, D-72074 Tubingen, Germany

[3] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PA, England

[4] Univ Southampton, Canc Sci Unit, Antibody & Vaccine Grp, Southampton SO16 6YD, Hants, England

[5] Univ Med Ctr Hamburg Eppendorf, Res Dept Cell & Gene Therapy, D-20246 Hamburg, Germany

[6] Univ Basque Country, Ikerbasque Fdn, Achucarro Basque Ctr Neurosci, UPV EHU, Leioa 48940, Bizkaia, Spain

来源：

CELL REPORTS | 2017年 / 18卷 / 02期

基金：

英国医学研究理事会;

关键词：

TISSUE-RESIDENT MACROPHAGES; CENTRAL-NERVOUS-SYSTEM; IN-VIVO; CHRONIC NEURODEGENERATION; HIPPOCAMPAL NEUROGENESIS; TRANSGENIC MICE; MOUSE BRAIN; CELLS; REVEALS; LIFE;

D O I：

10.1016/j.celrep.2016.12.041

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived andmaintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.

引用

页码：391 / 405

页数：15

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