TFCat: the curated catalog of mouse and human transcription factors

被引：150

作者：

Fulton, Debra L. ^{[4
]}

Sundararajan, Saravanan ^{[1
,2
,3
]}

Badis, Gwenael ^{[5
]}

Hughes, Timothy R. ^{[5
]}

Wasserman, Wyeth W. ^{[4
]}

Roach, Jared C. ^{[6
]}

Sladek, Rob ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ H3A 1A4, Canada

[2] McGill Univ, Dept Human Genet, Montreal, PQ H3A 1A4, Canada

[3] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada

[4] Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canada

[5] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada

[6] Seattle Childrens Res Inst, Ctr Dev Therapeut, Seattle, WA USA

来源：

GENOME BIOLOGY | 2009年 / 10卷 / 03期

关键词：

DATABASE; EXPRESSION; PROTEINS; GENES; SEQUENCE; DOMAINS; CLASSIFICATION; KNOWLEDGEBASE; SUPERFAMILY; EVOLUTION;

D O I：

10.1186/gb-2009-10-3-r29

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Unravelling regulatory programs governed by transcription factors (TFs) is fundamental to understanding biological systems. TFCat is a catalog of mouse and human TFs based on a reliable core collection of annotations obtained by expert review of the scientific literature. The collection, including proven and homology-based candidate TFs, is annotated within a function-based taxonomy and DNA-binding proteins are organized within a classification system. All data and user-feedback mechanisms are available at the TFCat portal http://www.tfcat.ca.

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页数：14

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