Projected impact of a multigene pharmacogenetic test to optimize medication prescribing in cardiovascular patients

被引：15

作者：

Dong, Olivia M. ^{[1
,2
]}

Li, Amy ^{[1
]}

Suzuki, Oscar ^{[1
,2
]}

Oni-Orisan, Akinyemi ^{[3
,4
]}

Gonzalez, Ricardo ^{[1
,2
]}

Stouffer, George A. ^{[5
,6
]}

Lee, Craig R. ^{[1
,2
,5
]}

Wiltshire, Tim ^{[1
,2
,7
]}

机构：

[1] Univ North Carolina Chapel Hill, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, Ctr Pharmacogen & Individualized Therapy, Chapel Hill, NC 27599 USA

[3] Univ Calif San Francisco, UCSF Sch Pharm, Dept Clin Pharm, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

[5] Univ North Carolina Chapel Hill, UNC McAllister Heart Inst, Chapel Hill, NC 27599 USA

[6] Univ North Carolina Chapel Hill, UNC Sch Med, Div Cardiol, Chapel Hill, NC 27599 USA

[7] Univ North Carolina Chapel Hill, Dept Genet, Chapel Hill, NC 27599 USA

来源：

PHARMACOGENOMICS | 2018年 / 19卷 / 09期

关键词：

cardiovascular pharmacogenetics; multigene testing; pharmacogenetics; pharmacogenomics; pre-emptive genotyping; IMPLEMENTATION CONSORTIUM GUIDELINES; CORONARY-ARTERY-DISEASE; CYP2C19; GENOTYPE; INTERVENTION;

D O I：

10.2217/pgs-2018-0049

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: To determine the projected impact of a multigene pharmacogenetic (PGx) test on medication prescribing. Materials & methods: A retrospective analysis was conducted with 122 cardiac catheterization laboratory patients undergoing angiography for eligibility of potential PGx-guided interventions that could have occurred if multigene PGx information was pre-emptively available at the time of the procedure. Medication data and presence of actionable at-risk genotypes were used to determine eligibility of a PGx intervention. Results: 20% of the study population (n = 24) would have qualified for at least one PGx-based medication intervention per US FDA or Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines within 6 months of their cardiac catheterization procedure. Commonly encountered gene-drug pairs for these interventions included: CYP2C19 for clopidogrel and antidepressants, CYP2D6 for antidepressants and codeine, SLCO1B1 for simvastatin, and VKORC1/CYP2C9 for warfarin. Conclusion: Pre-emptive use of a multigene PGx test in the cardiac catheterization laboratory offers potential to reduce adverse medication outcomes.

引用

页码：771 / 782

页数：12

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