Elastic rod model of a DNA loop in the lac operon

被引：70
作者：
Balaeff, A [1 ]
Mahadevan, L
Schulten, K
机构：
[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
[2] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA
[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA
[4] Univ Illinois, Dept Phys, Urbana, IL 61801 USA
来源：
PHYSICAL REVIEW LETTERS | 1999年 / 83卷 / 23期
关键词：
D O I：
10.1103/PhysRevLett.83.4900
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We use the theory of elasticity to compute the shape of the DNA loop bridging the gap in the crystal structure of the lac repressor-DNA complex. The Kirchhoff system of equations with boundary conditions derived from the crystal structure is solved using a continuation method. This approach can be applied effectively to find coarse-grained conformational minima of DNA loops.
引用
收藏
页码：4900 / 4903
页数：4
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