Meningiomas from a developmental perspective: exploring the crossroads between meningeal embryology and tumorigenesis

被引：25

作者：

Boetto, Julien ^{[1
]}

Peyre, Matthieu ^{[2
]}

Kalamarides, Michel ^{[2
]}

机构：

[1] Montpellier Univ, Med Ctr, Gui de Chauliae Hosp, Neurosurg Dept, 91 Ave Augustin Fliche, F-34090 Montpellier, France

[2] Sorbonne Univ, Grp Hosp Univ Pitie Salpetriere, APHP, Neurosurg Dept, Paris, France

来源：

ACTA NEUROCHIRURGICA | 2021年 / 163卷 / 01期

关键词：

Meningioma; Embryological development; PROSTAGLANDIN-D SYNTHASE; CENTRAL-NERVOUS-SYSTEM; BETA-TRACE; MULTIPLE MENINGIOMAS; TUMOR-LOCALIZATION; GENE-EXPRESSION; SONIC HEDGEHOG; TISSUE ORIGINS; SKULL BASE; CELL;

D O I：

10.1007/s00701-020-04650-w

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Meningiomas are tumors arising from the meninges and represent the most frequent central nervous system tumors in adults. Recent large-scale genetic studies and preclinical meningioma mouse modelling led to a better comprehension of meningioma development and suggested evidences of close relationships between meningeal embryology and tumorigenesis. In this non-systematic review, we summarize the current knowledge on meningeal embryology and developmental biology, and illustrate how meningioma tumorigenesis is deeply related to meningeal embryology, concerning the potential cell of origin, the role of reactivation of embryonic stem cells, the influence of the embryonic tissue of origin, and the parallelism between topography-dependant molecular pathways involved in normal meninges and in meningioma development. Our study emphasizes why future studies on meningeal embryology are mandatory to affine our comprehension of mechanisms underlying meningioma initiation and development.

引用

页码：57 / 66

页数：10

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