Conditioned medium derived from mesenchymal stem cells culture as a intravesical therapy for cystitis interstitials

被引：18
作者：
Adamowicz, Jan [1 ]
Pokrywczynska, Marta [1 ]
Drewa, Tomasz [1 ,2 ]
机构：
[1] Nicolaus Copernicus Univ, Fac Med, Dept Tissue Engn, PL-85092 Bydgoszcz, Poland
[2] Nicolaus Copernicus Hosp Batory, Dept Urol, Torun, Poland
来源：
MEDICAL HYPOTHESES | 2014年 / 82卷 / 06期
关键词：
POSTERIOR TIBIAL NERVE; ANTIPROLIFERATIVE FACTOR; STROMAL CELLS; IN-VITRO; PROLIFERATION; FIBROBLAST; GROWTH; FAILURE; MODEL;
D O I：
10.1016/j.mehy.2014.02.027
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The treatment of Interstinal Cystitisis (IC) is still challenge for urologist. Available therapies do not result in long-term control of symptoms and do not provide pain relive to patients. Unique abilities of mesenchymal stem cells (MSC) could be used to develop new treatment approaches for Interstitial Cystitis. Conditioned Medium (CM) derived from MSC culture is rich in plenty of growth factors, cytokines and trophic agents which were widely reported to enhance regeneration of urinary bladder in different conditions. This ready mixture of growth factors could be used to develop intravesical therapy for patients with IC. MSC-CM has anti-apoptotic, anti-inflammatory, supportive, angiogenic, immunosuppressive and immunomodulative properties and seems to be ideal substance to prevent IC recurrence and to create favorable environment for regeneration of damaged bladder wall. (C) 2014 Published by Elsevier Ltd.
引用
收藏
页码：670 / 673
页数：4
相关论文
共 49 条
[1]   Tissue engineering of urinary bladder - current state of art and future perspectives [J].
Adamowicz, Jan ;
Kowalczyk, Tomasz ;
Drewa, Tomasz .
CENTRAL EUROPEAN JOURNAL OF UROLOGY, 2013, 66 (02) :202-206
[2]   Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis [J].
Altuntas, Cengiz Z. ;
Daneshgari, Firouz ;
Sakalar, Cagri ;
Goksoy, Esen ;
Gulen, M. Fatih ;
Kavran, Michael ;
Qin, Jun ;
Li, Xiaoxia ;
Tuohy, Vincent K. .
EUROPEAN UROLOGY, 2012, 61 (01) :193-200
[3]   Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury [J].
Angoulvant, Denis ;
Ivanes, Fabrice ;
Ferrera, Rene ;
Matthews, Phoebe G. ;
Nataf, Serge ;
Ovize, Michel. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (01) :95-102
[4]  
Bassuk JA, 2003, ADV EXP MED BIOL, V539, P623
[5]   Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion [J].
Bodin, Aase ;
Bharadwaj, Shantaram ;
Wu, Shaofeng ;
Gatenholm, Paul ;
Atala, Anthony ;
Zhang, Yuanyuan .
BIOMATERIALS, 2010, 31 (34) :8889-8901
[6]   Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis [J].
Chai, TC ;
Zhang, CO ;
Shoenfelt, JL ;
Johnson, HW ;
Warren, JW ;
Keay, S .
JOURNAL OF UROLOGY, 2000, 163 (05) :1440-1444
[7]   Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing [J].
Chen, Liwen ;
Tredget, Edward E. ;
Wu, Philip Y. G. ;
Wu, Yaojiong .
PLOS ONE, 2008, 3 (04)
[8]   Adult human circulating CD34-Lin-CD45-CD133- cells can differentiate into hematopoietic and endothelial cells [J].
Ciraci, Elisa ;
Della Bella, Silvia ;
Salvucci, Ombretta ;
Rofani, Cristina ;
Segarra, Marta ;
Bason, Caterina ;
Molinari, Agnese ;
Maric, Dragan ;
Tosato, Giovanna ;
Berardi, Anna C. .
BLOOD, 2011, 118 (08) :2105-2115
[9]   Tissue engineering for the oncologic urinary bladder [J].
Drewa, Tomasz ;
Adamowicz, Jan ;
Sharma, Arun .
NATURE REVIEWS UROLOGY, 2012, 9 (10) :561-572
[10]   Erythropoietin Gene-enhanced Marrow Mesenchymal Stromal Cells Decrease Cisplatin-induced Kidney Injury and Improve Survival of Allogeneic Mice [J].
Eliopoulos, Nicoletta ;
Zhao, Jing ;
Forner, Kathy ;
Birman, Elena ;
Young, Yoon Kow ;
Bouchentouf, Manaf .
MOLECULAR THERAPY, 2011, 19 (11) :2072-2083
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