Opioid receptor polymorphisms and opioid abuse

被引：7

作者：

Lee, NM ^{[1
]}

Smith, AP ^{[1
]}

机构：

[1] Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94115 USA

来源：

PHARMACOGENOMICS | 2002年 / 3卷 / 02期

关键词：

analgesia; drug abuse; G-protein-coupled receptor; morphine; mu opioid receptor; opioid tolerance; signal transduction; SNP;

D O I：

10.1517/14622416.3.2.219

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how a Iterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency with certain population groups who may be particularly susceptible to certain diseases. The g opioid receptor (MOR), which mediates the clinically important analgesic effects of drugs like morphine as well as the euphoria sought by heroin abusers, exhibits several dozen polymorphisms. Several of these are associated with altered receptor function and individuals at risk for drug abuse.

引用

页码：219 / 227

页数：9

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