Nitric oxide, a protective molecule in the cardiovascular system

被引：144
作者：
Lei, Jing [1 ]
Vodovotz, Yoram [1 ]
Tzeng, Edith [1 ]
Billiar, Timothy R. [1 ]
机构：
[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USA
来源：
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2013年 / 35卷
关键词：
Nitric oxide; Endothelial cell; Smooth muscle cell; Blood vessel injury; Intimal hyperplasia; Transplant vasculopathy; SMOOTH-MUSCLE-CELLS; CORONARY-ARTERY-DISEASE; CARDIAC ALLOGRAFT VASCULOPATHY; RAT CAROTID-ARTERY; FIBROBLAST-GROWTH-FACTOR; SYNTHASE GENE-TRANSFER; SERIAL INTRAVASCULAR ULTRASOUND; HEART-TRANSPLANT RECIPIENTS; GRAFT INTIMAL HYPERPLASIA; DEPENDENT PROTEIN-KINASE;
D O I：
10.1016/j.niox.2013.09.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell. and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：175 / 185
页数：11
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