Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries

Different types of leukemia are characterized by different patterns of nonrandom chromosomal aberrations, but the frequencies with which the various karyotypic subtypes are seen differ among cytogenetic laboratories, countries, and geographic regions. During the 12-yr period 1986-1997, a total of 2054 children (<15 yr of age) were diagnosed with acute lymphoblastic leukemia (ALL) in the five Nordic countries (Denmark, Finland, Iceland. Norway, and Sweden). Cytogenetic analyses were successfully performed in 1372 patients, 787 (57%) of whom displayed clonal chromosomal abnormalities. ALL with greater than or equal to 47 chromosomes was the most frequent cytogenetic subgroup (63%), with massive hyperdiploidy (greater than or equal to 52 chromosomes) and chromosome numbers in the tri- and tetraploid range, constituting 46% of all abnormal cases. ALL-associated translocations were found at low frequencies [11q23 translocations in 3.7%, t(9;22)(q34;q11) or del(22q) in 2-2%, t(4;11)(q21;q23) in 2.0%, t(11;19)(q23;p13) in 1.4%, t(1;19)(q23:p13) in 1.3%, and t(8;14)(q24;q32) in 1%]. Two rearrangements not previously reported in childhood ALL, but recurrent in this population-based material, were identified: der(7;9)(q10;q10) and t(9;12)(q22;p11-12), the molecular genetic consequences of which are unknown. Hyperdiploid childhood leukemias, especially those with a high hyperdiploid modal number, thus seem to be more frequent and ALL-specific translocations less frequent in the Nordic countries than in other geographic regions. Although technical differences among laboratories cannot be ruled out as a cause of at least some of the frequency differences observed compared with previous studies, systematic differences in exposure to environmental oncogenic factors or in geographic/ethnic origin are an intriguing possibility.