Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation

被引：34

作者：

Krause, KP ^{[1
]}

Kayser, O ^{[1
]}

Mäder, K ^{[1
]}

Gust, R ^{[1
]}

Müller, RH ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Pharmaceut Biopharmaceut & Biotechnol, D-12196 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 196卷 / 02期

关键词：

nanosuspensions; heavy metal contamination; high pressure homogenisation; metal erosion;

D O I：

10.1016/S0378-5173(99)00414-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

High pressure homogenisation is a method for the production of nanosuspensions. In this process crystalline drug particles are pressed with high pressure through a narrow homogenisation gap, Due to the conditions in the gap it seems possible that metal erosion can occur. In this study the heavy metal (Fe) contamination of nanosuspensions produced by high pressure homogenisation was determined. Therefore nanosuspensions were analysed by atom absorption spectroscopy concerning their load of iron which is chosen as reference metal. The results show that the erosion of metal is below 1 ppm and will not cause any toxicological problems. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：169 / 172

页数：4