The UniProtKB guide to the human proteome

被引：108

作者：

Breuza, Lionel ^{[1
]}

Poux, Sylvain ^{[1
]}

Estreicher, Anne ^{[1
]}

Famiglietti, Maria Livia ^{[1
]}

Magrane, Michele ^{[2
]}

Tognolli, Michael ^{[1
]}

Bridge, Alan ^{[1
]}

Baratin, Delphine ^{[1
]}

Redaschi, Nicole ^{[1
]}

Xenarios, Ioannis ^{[4
]}

Bougueleret, Lydie ^{[4
]}

Bairoch, Amos ^{[4
]}

Aimo, Lucila ^{[4
]}

Auchincloss, Andrea ^{[4
]}

Axelsen, Kristian ^{[4
]}

Argoud-Puy, Ghislaine ^{[4
]}

Bansal, Parit ^{[4
]}

Binz, Pierre-Alain ^{[4
]}

Blatter, Marie-Claude ^{[4
]}

Boeckmann, Brigitte ^{[4
]}

Bolleman, Jerven ^{[4
]}

Boutet, Emmanuel ^{[4
]}

Braconi-Quintaje, Silvia ^{[4
]}

Casal-Casas, Cristina ^{[4
]}

de Castro, Edouard ^{[4
]}

Cerutti, Lorenzo ^{[4
]}

Coudert, Elisabeth ^{[4
]}

Cuche, Beatrice ^{[4
]}

Cusin, Isabelle ^{[4
]}

Doche, Mikael ^{[4
]}

Dornevil, Dolnide ^{[4
]}

Duvaud, Severine ^{[4
]}

Ferro-Rojas, Serenella ^{[4
]}

Feuermann, Marc ^{[4
]}

Gasteiger, Elisabeth ^{[4
]}

Gehant, Sebastien ^{[4
]}

Gerritsen, Vivienne ^{[4
]}

Gos, Arnaud ^{[4
]}

Gruaz-Gumowski, Nadine ^{[4
]}

Hinz, Ursula ^{[4
]}

Hulo, Chantal ^{[4
]}

James, Janet ^{[4
]}

Jimenez, Silvia ^{[4
]}

Jungo, Florence ^{[4
]}

Keller, Guillaume ^{[4
]}

Kerhornou, Arnaud ^{[4
]}

Kappler, Thomas ^{[4
]}

Lane, Lydie ^{[4
]}

Lara, Vicente ^{[4
]}

Lemercier, Philippe ^{[4
]}

机构：

[1] Ctr Med Univ Geneva, SIB Swiss Inst Bioinformat, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland

[2] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Wellcome Trust Genome Campus, Cambridge CB10 1SD, England

[3] Georgetown Univ, Med Ctr, Prot Informat Resource, 3300 Whitehaven St North West,Suite 1200, Washington, DC 20007 USA

[4] SIB, Lausanne, Switzerland

[5] European Bioinformat Inst, Cambridge, England

[6] Prot Informat Resource, Newark, DE USA

来源：

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2016年

基金：

美国国家卫生研究院;

关键词：

DRAFT; MAP;

D O I：

10.1093/database/bav120

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Advances in high-throughput and advanced technologies allow researchers to routinely perform whole genome and proteome analysis. For this purpose, they need high-quality resources providing comprehensive gene and protein sets for their organisms of interest. Using the example of the human proteome, we will describe the content of a complete proteome in the UniProt Knowledgebase (UniProtKB). We will show how manual expert curation of UniProtKB/Swiss-Prot is complemented by expert-driven automatic annotation to build a comprehensive, high-quality and traceable resource. We will also illustrate how the complexity of the human proteome is captured and structured in UniProtKB.

引用

页数：10

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