Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling

被引：73

作者：

Jensen, MS ^{[1
]}

Yang, CH ^{[1
]}

Hsiao, Y ^{[1
]}

Rivera, N ^{[1
]}

Wells, KM ^{[1
]}

Chung, JYL ^{[1
]}

Yasuda, N ^{[1
]}

Hughes, DL ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 08期

关键词：

D O I：

10.1021/ol005641d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis of carbapenem 1 is described. The key step involves the cross-coupling of an enol triflate with an amino-substituted sp(3) carbon. This cross-couping, which allows the introduction of the complete side chain in one step, utilizes a stannatrane as the heteroalkyl transfer reagent.

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页码：1081 / 1084

页数：4

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