National and international guidelines for neonatal caffeine use: Are they evidenced-based?

被引：10

作者：

Eichenwald, Eric C. ^{[1
,2
]}

机构：

[1] Univ Penn, Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Neonatol, Philadelphia, PA 19104 USA

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2020年 / 25卷 / 06期

关键词：

Caffeine; Prematurity; Apnea; Drug safety; Clinical trial; Bronchopulmonary dysplasia; Neurodevelopment; EUROPEAN CONSENSUS GUIDELINES; BRAIN-DEVELOPMENT; THERAPY; APNEA; PREMATURITY; MANAGEMENT; ASSOCIATION; DISABILITY;

D O I：

10.1016/j.siny.2020.101177

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The Caffeine for Apnea of Prematurity (CAP) trial showed that caffeine was safe when used with standard dosing and provided both pulmonary and neurological benefits to preterm infants. Since its publication almost 15 years ago, the use of caffeine in extremely premature infants in Newborn Intensive Care Units worldwide has increased, with almost all receiving the drug during their hospital stay. Subsequent observational studies suggested that administration of caffeine before 3 days of age may have greater benefits, leading many neonatologists to start caffeine prophylactically in all very low birth weight infants. Several publicly available national and international guidelines on caffeine advocate prophylactic use, and some recommend higher doses than those used in the CAP trial. This article will review the evidence basis for neonatal caffeine therapy in light of these guidelines.

引用

页数：4

共 23 条

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