Novel, efficient, and green procedure for the Knoevenagel condensation catalyzed by diammonium hydrogen phosphate in water

被引：50

作者：

Balalaie, Saeed

Bararjanian, Morteza

Hekmat, Shohreh

Salehi, Peyman

机构：

[1] KN Toosi Univ Technol, Dept Chem, Tehran, Iran

[2] Islamic Azad Univ, N Tehran Branch, Dept Chem, Tehran, Iran

[3] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, Tehran, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 17期

关键词：

alkene; diamamonium hydrogen phosphate; Knoevenagel condensation; water;

D O I：

10.1080/00397910600781471

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammonium hydrogen phosphate. The reactions were carried out at room temperature in short periods with very simple workup procedure and good to high yields.

引用

页码：2549 / 2557

页数：9

共 42 条

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