Novel, efficient, and green procedure for the Knoevenagel condensation catalyzed by diammonium hydrogen phosphate in water

被引：50
作者：
Balalaie, Saeed
Bararjanian, Morteza
Hekmat, Shohreh
Salehi, Peyman
机构：
[1] KN Toosi Univ Technol, Dept Chem, Tehran, Iran
[2] Islamic Azad Univ, N Tehran Branch, Dept Chem, Tehran, Iran
[3] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, Tehran, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 17期
关键词：
alkene; diamamonium hydrogen phosphate; Knoevenagel condensation; water;
D O I：
10.1080/00397910600781471
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like methyl and ethyl cyanoacetate, malononitrile, and cyanoacetamide proceeds smoothly with stirring in water in the presence of 4 mol% of diammonium hydrogen phosphate. The reactions were carried out at room temperature in short periods with very simple workup procedure and good to high yields.
引用
收藏
页码：2549 / 2557
页数：9
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