PACAP and NAP: Effect of Two Functionally Related Peptides in Diabetic Retinopathy

被引：26
作者：
D'Amico, Agata Grazia [1 ]
Maugeri, Grazia [2 ]
Musumeci, Giuseppe [2 ]
Reglodi, Dora [3 ]
D'Agata, Velia [2 ]
机构：
[1] Univ Catania, Dept Drug Sci, Catania, Italy
[2] Univ Catania, Dept Biomed & Biotechnol Sci, Sect Anat Histol & Movement Sci, Catania, Italy
[3] Univ Pecs, Dept Anat, MTA PTE PACAP Res Grp, Med Sch, Pecs, Hungary
来源：
JOURNAL OF MOLECULAR NEUROSCIENCE | 2021年 / 71卷 / 08期
关键词：
Diabetic retinopathy; PACAP; ADNP; NAP; Hyperglycemia; CYCLASE-ACTIVATING POLYPEPTIDE; DEPENDENT NEUROPROTECTIVE PROTEIN; VASOACTIVE-INTESTINAL-PEPTIDE; HYPOXIA-INDUCIBLE FACTORS; INDUCED RETINAL LESION; ADENYLATE-CYCLASE; MOLECULAR-CLONING; VEGF EXPRESSION; NERVOUS-SYSTEM; MESSENGER-RNA;
D O I：
10.1007/s12031-020-01769-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptide involved in physio-pathological processes of the eye. It exerts multiple effects directly through activation of its related receptors and indirectly through increases in the synthesis of activity-dependent neuroprotective protein (ADNP). To study the role of ADNP and protect against ADNP deficiencies, a small peptide called NAP was synthetized. It includes an eight amino acid active site sequence of ADNP. In this review, we summarize the knowledge regarding the neuroprotective function played by PACAP and NAP in retinal tissue and provide an overview of the correlation between PACAP and ADNP in the context of diabetic retinopathy.
引用
收藏
页码：1525 / 1535
页数：11
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