Trichodysplasia spinulosa - A newly described folliculocentric viral infection in an immunocompromised host

被引:100
作者
Haycox, CL
Kim, S
Fleckman, P
Smith, LT
Piepkorn, M
Sundberg, JP
Howell, DN
Miller, SE
机构
[1] Univ Washington, Div Dermatol, Dept Med Dermatol, Seattle, WA 98195 USA
[2] Jackson Lab, Bar Harbor, ME 04609 USA
[3] Duke Univ, Vet Affairs Med Ctr, Durham, NC USA
[4] Duke Univ, Med Ctr, Dept Microbiol, Durham, NC 27710 USA
[5] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
关键词
hair follicle; viral infection; immunosuppression;
D O I
10.1038/sj.jidsp.5640227
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
This is a case report of an immunocompromised individual who presented with progressive alopecia, friable follicular spinous processes, and erythematous, indurated papules. Examination of skin biopsies using light microscopy and immunohistochemistry revealed pathologic changes of the follicular inner root sheath epithelium with dystrophic trichohyaline granules. Electron microscopy of thin sections of tissue revealed intracellular viral particles with a size and appearance consistent with those in the Papovaviridae family. Electron microscopy of negatively stained extract from a homogenized lesion also demonstrated icosahedral viruses with papovavirus morphology. We believe this is a previously unreported folliculocentric viral infection in an immunosuppressed human host and have termed this entity "trichodysplasia spinulosa".
引用
收藏
页码:268 / 271
页数:4
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