Simulated gastrointestinal digestion and in vitro colonic fermentation of spent coffee (Coffea arabica L): Bioaccessibility and intestinal permeability

被引：87

作者：

Campos-Vega, R. ^{[1
]}

Vazquez-Sanchez, K. ^{[1
]}

Lopez-Barrera, D. ^{[1
]}

Loarca-Pina, G. ^{[1
]}

Mendoza-Diaz, S. ^{[1
]}

Oomah, B. D. ^{[2
]}

机构：

[1] Univ Autonoma Queretaro, Sch Chem, Res & Grad Studies Food Sci, Programa Posgrad Alimentos Ctr Republ PROPAC, Santiago De Queretaro 76010, Qro, Mexico

[2] Agr & Agri Food Canada, Natl Bioprod & Bioproc Program, Pacific Agri Food Res Ctr, Summerland, BC V0H 1Z0, Canada

来源：

FOOD RESEARCH INTERNATIONAL | 2015年 / 77卷

关键词：

Spent coffee; Bioaccessibility; Permeability; Antioxidant activity; In vitro gastrointestinal digestion; in vitro colonic fermentation; PHENOLIC-COMPOUNDS; ANTIOXIDANT ACTIVITY; DRUG ABSORPTION; POLYPHENOLS; DELIVERY; CAFFEINE; GREEN;

D O I：

10.1016/j.foodres.2015.07.024

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Spent coffee, a waste produced after beverage preparation, contains large amounts of several human health related compounds. The bioaccessibility, permeability and antioxidant activity of phenolic compounds from spent coffee (medium and dark-roasted) were evaluated using an in vitro gastrointestinal assay, intestinal absorption and colonic fermentation of non-digestible spent coffee fraction. Digested samples displayed lower amounts of phenolic compounds and flavonoids, but higher antioxidant activity (1-8 folds) compared to their respective non-digested (undigested) controls due to high release of condensed tannins at the colonic stage. SC polyphenols released during simulated GI digestion scavenged free radicals and these antioxidants increased during the transition from acidic to alkaline environment rapidly permeating through the small intestine by passive diffusion. Our results highlight the in vivo potential physiological role of SC phenolic compounds to scavenge free radicals present in the systemic circulation and target tissues, suggesting their potential health benefits and justifying their value addition. Further studies are needed to elucidate the clinical implication of these findings in human subjects. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：156 / 161

页数：6

共 38 条

[11] The influence of beverage composition on delivery of phenolic compounds from coffee and tea [J].

Ferruzzi, Mario G. .

PHYSIOLOGY & BEHAVIOR, 2010, 100 (01) :33-41

[12] In vitro bioaccessibility and gut biotransformation of polyphenols present in the water-insoluble cocoa fraction [J].

Fogliano, Vincenzo ;

Corollaro, Maria Laura ;

Vitaglione, Paola ;

Napolitano, Aurora ;

Ferracane, Rosalia ;

Travaglia, Fabiano ;

Arlorio, Marco ;

Costabile, Adele ;

Klinder, Annett ;

Gibson, Glenn .

MOLECULAR NUTRITION & FOOD RESEARCH, 2011, 55 :S44-S55

[13] Assessing antioxidant and prooxidant activities of phenolic compounds [J].

Fukumoto, LR ;

Mazza, G .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (08) :3597-3604

[14] Saliva increases the availability of lipophilic polyphenols as antioxidants and enhances their retention in the oral cavity [J].

Ginsburg, Isaac ;

Koren, Erez ;

Shalish, Miri ;

Kanner, Joseph ;

Kohen, Ron .

ARCHIVES OF ORAL BIOLOGY, 2012, 57 (10) :1327-1334

[15]

GRANFELDT Y, 1992, EUR J CLIN NUTR, V46, P649

[16] Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers [J].

Hubatsch, Ina ;

Ragnarsson, Eva G. E. ;

Artursson, Per .

NATURE PROTOCOLS, 2007, 2 (09) :2111-2119

[17] Effect of in vitro exposure to Vibrio vulnificus on hydroelectrolytic transport and structural changes of sea bream (Sparus aurata L.) intestine [J].

Khemiss, Fathia ;

Ahmadi, Salwa ;

Massoudi, Raja ;

Ghoul-Mazgar, Sonia ;

Safta, Sihem ;

Moshtaghie, Ali Asghar ;

Saidane, Dalila .

FISH PHYSIOLOGY AND BIOCHEMISTRY, 2009, 35 (03) :541-549

[18] Comparative Study of Two In Vitro Methods for Assessing Drug Absorption: Sartorius SM 16750 Apparatus Versus Everted Gut Sac [J].

Lassoued, Mohamed Ali ;

Khemiss, Fathia ;

Sfar, Souad .

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2011, 14 (01) :117-127

[19] Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract [J].

Lee, MJ ;

Lambert, JD ;

Prabhu, S ;

Meng, XF ;

Lu, H ;

Maliakal, P ;

Ho, CT ;

Yang, CS .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2004, 13 (01) :132-137

[20] Increased Systemic Exposure to Rhizoma Coptidis Alkaloids in Lipopolysaccharide-Pretreated Rats Attributable to Enhanced Intestinal Absorption [J].

Ma, Bing-Liang ;

Yao, Meng-Kan ;

Zhong, Jie ;

Ma, Yue-Ming ;

Gao, Cheng-Lu ;

Wu, Jia-Sheng ;

Qiu, Fu-Rong ;

Wang, Chang-Hong ;

Wang, Xin-Hong .

DRUG METABOLISM AND DISPOSITION, 2012, 40 (02) :381-388

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