Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30

被引：10

作者：

Cramarossa, Gemma ^{[1
]}

Zeng, Liang ^{[1
]}

Zhang, Liying ^{[1
]}

Tseng, Ling-Ming ^{[2
]}

Hou, Ming-Feng ^{[3
]}

Fairchild, Alysa ^{[4
]}

Vassiliou, Vassilios ^{[5
]}

Jesus-Garcia, Reynaldo ^{[6
]}

El-Din, Mohamed A. Alm ^{[7
]}

Kumar, Aswin ^{[8
]}

Forges, Fabien ^{[9
,10
]}

Chie, Wei-Chu ^{[11
,12
]}

Sahgal, Arjun ^{[1
]}

Lam, Henry ^{[1
]}

Pulenzas, Natalie ^{[1
]}

Chow, Edward ^{[1
]}

机构：

[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Radiat Oncol, Odette Canc Ctr, Toronto, ON M4N 3M5, Canada

[2] Natl Yang Ming Univ, Taipei Vet Gen Hosp, Dept Surg, Taipei 112, Taiwan

[3] Kaohsiung Med Univ Hosp, Dept Surg Gastroenterol, Kaohsiung, Taiwan

[4] Cross Canc Inst, Dept Radiat Oncol, Edmonton, AB T6G 1Z2, Canada

[5] Bank Cyprus, Dept Radiat Oncol, Ctr Oncol, Nicosia, Cyprus

[6] Univ Fed Sao Paulo, Dept Orthoped Oncol, Sao Paulo, Brazil

[7] Tanta Univ Hosp, Tanta Fac Med, Dept Clin Oncol, Tanta, Egypt

[8] Reg Canc Ctr, Div Gynaecol & Genitourinary Oncol, Dept Radiat Oncol, Trivandrum 695011, Kerala, India

[9] St Etienne Univ Hosp, INSERM, CIE3, St Etienne, France

[10] St Etienne Univ Hosp, Unit Clin Res Innovat & Pharmacol, St Etienne, France

[11] Natl Taiwan Univ, Dept Publ Hlth, Taipei 10764, Taiwan

[12] Natl Taiwan Univ, Inst Epidemiol & Preventat Med, Taipei 10764, Taiwan

来源：

EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH | 2014年 / 14卷 / 01期

关键词：

advanced cancer; EORTC QLQ-C30; metastatic cancer; quality of life; symptom control; BRAIN METASTASES; BREAST-CANCER; FATIGUE; PAIN; RADIOTHERAPY; PREVALENCE; SYMPTOMS; DETERMINANTS; ASSOCIATION; MANAGEMENT;

D O I：

10.1586/14737167.2014.864560

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Objective: To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients. Methods: Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30). Results: Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. In the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. In patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL. Conclusion: Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.

引用

页码：139 / 146

页数：8

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