Total synthesis of eleutherobin

被引:105
作者
Nicolaou, KC
vanDelft, F
Ohshima, T
Vourloumis, D
Xu, JY
Hosokawa, S
Pfefferkorn, J
Kim, S
Li, TH
机构
[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA
[2] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA
来源
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1997年 / 36卷 / 22期
关键词
antitumor agents; eleuthrobin; natural products; structure-activity relationships; total synthesis;
D O I
10.1002/anie.199725201
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:2520 / 2524
页数:5
相关论文
共 28 条
[11]   Epothilone A and B - Novel 16-membered macrolides with cytotoxic activity: Isolation, crystal structure, and conformation in solution [J].
Hofle, GH ;
Bedorf, N ;
Steinmetz, H ;
Schomburg, D ;
Gerth, K ;
Reichenbach, H .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (13-14) :1567-1569
[12]   Sarcodictyin A and two novel diterpenoid glycosides, eleuthosides A and B, from the soft coral Eleutherobia aurea [J].
Ketzinel, S ;
Rudi, A ;
Schleyer, M ;
Benayahu, Y ;
Kashman, Y .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (09) :873-875
[13]  
Kowalski RJ, 1997, J BIOL CHEM, V272, P2534
[14]   THE VALDIVONES, ANTIINFLAMMATORY DITERPENE ESTERS FROM THE SOUTH-AFRICAN SOFT CORAL ALCYONIUM-VALDIVAE [J].
LIN, YC ;
BEWLEY, CA ;
FAULKNER, DJ .
TETRAHEDRON, 1993, 49 (36) :7977-7984
[15]   Eleutherobin, a new cytotoxin that mimics paclitaxel (Taxol) by stabilizing microtubules [J].
Lindel, T ;
Jensen, PR ;
Fenical, W ;
Long, BH ;
Casazza, AM ;
Carboni, J ;
Fairchild, CR .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (37) :8744-8745
[16]  
LONG BH, UNPUB CANC RES
[17]   Synthesis of epothilones A and B in solid and solution phase [J].
Nicolaou, KC ;
Winssinger, N ;
Pastor, J ;
Ninkovic, S ;
Sarabia, F ;
He, Y ;
Vourloumis, D ;
Yang, Z ;
Li, T ;
Giannakakou, P ;
Hamel, E .
NATURE, 1997, 387 (6630) :268-272
[18]   Design, synthesis and biological evaluation of carbohydrate-based mimetics of cRGDFV [J].
Nicolaou, KC ;
Trujillo, JI ;
Chibale, K .
TETRAHEDRON, 1997, 53 (26) :8751-8778
[19]   Total syntheses of epothilones A and B via a macrolactonization-based strategy [J].
Nicolaou, KC ;
Ninkovic, S ;
Sarabia, F ;
Vourloumis, D ;
He, Y ;
Vallberg, H ;
Finlay, MRV ;
Yang, Z .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (34) :7974-7991
[20]  
NICOLAOU KC, IN PRESS J AM CHEM S