Vasoconstrictively acting AT1R A1166C and NOS3 4/5 polymorphisms in recurrent spontaneous abortions (RSA)

被引：19
作者：
Buchholz, T
Lohse, P
Kosian, E
Thaler, CJ [1 ]
机构：
[1] Univ Munich Klinikum, Dept Obstet & Gynecol Grosshadern, D-81377 Munich, Germany
[2] Univ Munich, Dept Clin Chem Grosshadern, Munich, Germany
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2004年 / 51卷 / 05期
关键词：
endothelial nitric oxide synthase; habitual miscarriages; placental perfusion; renin-angiotensin system;
D O I：
10.1111/j.1600-0897.2004.00163.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
PROBLEM: Inadequate uteroplacental perfusion is one of the main reasons for recurrent spontaneous abortions (RSA). Coagulation, fibrinolysis, and vasoconstriction affect tissue perfusion. These systems are regulated by different gene products. Polymorphisms can modulate the expression levels of the respective genes and can thereby affect perfusion. Vasoconstriction is influenced by the expression of endothelial nitric oxide synthase (eNOS) and of the angiotensinogen II type 1 receptor (AT1R). METHOD: The aim of our study was to investigate, whether two polymorphisms in the AT1R and NOS3 genes shown to result in maternal vasoconstriction are associated with an increased risk for RSA. RESULTS: Our data indicate that the vasoconstrictively acting genotypes AT1R C/C and NOS3 4/4 are of similar prevalence in RSA patients and in controls. CONCLUSION: Results do not show any influence of the polymorphisms studied on early pregnancy development. This is in concordance with the concept of an independent regulation of placental perfusion.
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收藏
页码：323 / 328
页数：6
相关论文
共 31 条
[1]  
Alhenc-Gelas F, 1986, Adv Nephrol Necker Hosp, V15, P25
[2]   Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease [J].
Alvarez, R ;
Reguero, JR ;
Batalla, A ;
Iglesias-Cubero, G ;
Cortina, A ;
Alvarez, V ;
Coto, E .
CARDIOVASCULAR RESEARCH, 1998, 40 (02) :375-379
[3]   Thrombophilia-associated pregnancy wastage [J].
Blumenfeld, Z ;
Brenner, B .
FERTILITY AND STERILITY, 1999, 72 (05) :765-774
[4]   Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia [J].
Bouba, I ;
Makrydimas, G ;
Kalaitzidis, R ;
Lolis, DE ;
Siamopoulos, KC ;
Georgiou, I .
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2003, 110 (01) :8-11
[5]   Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages [J].
Buchholz, T ;
Lohse, P ;
Rogenhofer, N ;
Kosian, E ;
Pihusch, R ;
Thaler, CJ .
HUMAN REPRODUCTION, 2003, 18 (11) :2473-2477
[6]  
Buraczynska Monika, 2003, Kardiol Pol, V58, P1
[7]   Variation at the angiotensin-converting enzyme and endothelial nitric oxide synthase genes is associated with the risk of esophageal varices among patients with alcoholic cirrhosis [J].
Coto, E ;
Rodrigo, L ;
Alvarez, R ;
Fuentes, D ;
Rodríguez, T ;
Menéndez, LG ;
Ciriza, C ;
González, P ;
Alvarez, V .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2001, 38 (06) :833-839
[8]   Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion [J].
Coumans, ABC ;
Huijgens, PC ;
Jakobs, C ;
Schats, R ;
de Vries, JIP ;
van Pampus, MG ;
Dekker, GA .
HUMAN REPRODUCTION, 1999, 14 (01) :211-214
[9]   Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes [J].
Duncan, JA ;
Scholey, JW ;
Miller, JA .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2001, 10 (01) :111-116
[10]   Angiotensin-converting enzyme DD genotype, angiotensin type 1 receptor CC genotype, and hyperhomocysteinemia increase first-trimester fetal-loss susceptibility [J].
Fatini, C ;
Gensini, F ;
Battaglini, B ;
Prisco, D ;
Cellai, AP ;
Fedi, S ;
Marcucci, R ;
Brunelli, T ;
Mello, G ;
Parretti, E ;
Pepe, G ;
Abbate, R .
BLOOD COAGULATION & FIBRINOLYSIS, 2000, 11 (07) :657-662
1234