Functional regeneration beyond the glial scar

被引：506
作者：
Cregg, Jared M. [1 ]
DePaul, Marc A. [1 ]
Filous, Angela R. [1 ]
Lang, Bradley T. [1 ]
Tran, Amanda [1 ]
Silver, Jerry [1 ]
机构：
[1] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA
来源：
EXPERIMENTAL NEUROLOGY | 2014年 / 253卷
关键词：
Regeneration; Spinal cord injury; Axon growth cone; Glial scar; Hypertrophy; Chondroitin sulfate proteoglycans; SPINAL-CORD-INJURY; CHONDROITIN SULFATE PROTEOGLYCANS; TYROSINE-PHOSPHATASE-SIGMA; CORTICOSPINAL TRACT AXONS; PERIPHERAL-NERVE GRAFTS; SCHWANN-CELL GRAFTS; NEURAL STEM-CELLS; IN-VITRO MODEL; ADULT-RAT; NEURITE OUTGROWTH;
D O I：
10.1016/j.expneurol.2013.12.024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon tips. Here we review evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury. We also consider several exciting new interventions that allow axons to regenerate beyond the glial scar, and discuss the implications of this work for the future of regeneration biology. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：197 / 207
页数：11
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