An Antifungal Tetrapeptide from the Culture of Penicillium canescens

被引：30

作者：

Bertinetti, Brenda V. ^{[1
,2
]}

Pena, Nora I. ^{[3
]}

Cabrera, Gabriela M. ^{[1
,2
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, UMYMFOR, RA-1428 Buenos Aires, DF, Argentina

[3] UNMdP, FCEyN, Dept Biol, Mar Del Plata, Buenos Aires, Argentina

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 08期

关键词：

CYCLIC DIPEPTIDES; ACID; PEPTIDES;

D O I：

10.1002/cbdv.200800336

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium callescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virgidiforme was determined by spectroscopic (2D-NMR, and MS and MS/MS) and chemical methods, and the sequence was confirmed by comparison with authentic synthetic isomeric peptides.

引用

页码：1178 / 1184

页数：7

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