The as-yet unfulfilled promise of p38 MAPK inhibitors

被引：32
|
作者：
Sweeney, Susan E. [1 ]
机构：
[1] Univ Calif San Diego, Sch Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA
来源：
NATURE REVIEWS RHEUMATOLOGY | 2009年 / 5卷 / 09期
关键词：
RHEUMATOID-ARTHRITIS; KINASE INHIBITOR; DOUBLE-BLIND; EFFICACY; VX-702; SAFETY;
D O I：
10.1038/nrrheum.2009.171
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Clinical tests of the novel small-molecule inhibitor of p38α maPK, VX-702, have resulted in an all-too-familiar outcome: Modest clinical efficacy and transient inhibition of inflammatory markers. Why have p38a inhibitors failed, and what can we learn about the regulation of signal transduction pathways in inflammatory arthritis?. © 2009 Macmillan Publishers Limited. All rights reserved.
引用
收藏
页码：475 / 477
页数：3
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