Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method

In this paper, a simple, rapid and sensitive flow-injection chemiluminescence method has been developed for the determination of metoprolol tartrate, which acts as a kind of sensitizer in the chemiluminescence emission from the redox Of SO32- with Ce(IV) in acidic medium. Under the optimized conditions, the proposed method allows the measurement of metoprolol tartrate over the range of 1.5 x 10(-8) to 7.3 x 10(-6) mol/L with a detection limit of 4.7 x 10(-9) mol/L (3 sigma), and the relative standard deviation for 7.3 x 10(-7) mol/L metoprolol tartrate (n = 11) is 2.20%. The utility of this method was demonstrated by determining metoprolol tartrate in tablets and human urine sample. (c) 2006 Published by Elsevier B.V.