Peroxynitrite signaling: Receptor tyrosine kinases and activation of stress-responsive pathways

被引:95
作者
Klotz, LO [1 ]
Schroeder, P [1 ]
Sies, H [1 ]
机构
[1] Univ Dusseldorf, Inst Physiol Chem 1, D-40001 Dusseldorf, Germany
关键词
stress signaling; signal transduction; reactive oxygen species; reactive nitrogen species;
D O I
10.1016/S0891-5849(02)00892-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Peroxynitrite, generated for example in inflammatory processes, is capable of nitrating and oxidizing biomolecules, implying a considerable impact on the integrity of cellular structures. Cells respond to stressful conditions by the activation of signaling pathways, including receptor tyrosine kinase-dependent pathways such as mitogen-activated protein kinases and the phosphoinositide-3-kinase/Akt pathway. Peroxynitrite affects signaling pathways by nitration as well as by oxidation: while nitration of tyrosine residues by peroxynitrite modulates signaling processes relying on tyrosine phosphorylation and dephosphorylation, oxidation of phosphotyrosine phosphatases may lead to an alteration in the tyrosine phosphorylation/dephosphorylation balance. The flavanol (-)-epicatechin is a potent inhibitor of tyrosine nitration and may be employed as a tool to distinguish signaling effects due to tyrosine nitration from those that are due to oxidation reactions. (C) 2002 Elsevier Science Inc.
引用
收藏
页码:737 / 743
页数:7
相关论文
共 59 条
  • [11] Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH2-terminal kinase
    Go, YM
    Patel, RP
    Maland, MC
    Park, H
    Beckman, JS
    Darley-Usmar, VM
    Jo, H
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (04): : H1647 - H1653
  • [12] Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation
    Gow, AJ
    Duran, D
    Malcolm, S
    Ischiropoulos, H
    [J]. FEBS LETTERS, 1996, 385 (1-2) : 63 - 66
  • [13] Selective interaction of JNK protein kinase isoforms with transcription factors
    Gupta, S
    Barrett, T
    Whitmarsh, AJ
    Cavanagh, J
    Sluss, HK
    Derijard, B
    Davis, RJ
    [J]. EMBO JOURNAL, 1996, 15 (11) : 2760 - 2770
  • [14] THE REACTION OF NO WITH SUPEROXIDE
    HUIE, RE
    PADMAJA, S
    [J]. FREE RADICAL RESEARCH COMMUNICATIONS, 1993, 18 (04): : 195 - 199
  • [15] PEROXYNITRITE FORMATION FROM MACROPHAGE-DERIVED NITRIC-OXIDE
    ISCHIROPOULOS, H
    ZHU, L
    BECKMAN, JS
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) : 446 - 451
  • [16] Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells
    Jope, RS
    Zhang, L
    Song, L
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 376 (02) : 365 - 370
  • [17] AP-1 function and regulation
    Karin, M
    Liu, ZG
    Zandi, E
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (02) : 240 - 246
  • [18] Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis
    Kissner, R
    Nauser, T
    Bugnon, P
    Lye, PG
    Koppenol, WH
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (11) : 1285 - 1292
  • [19] Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts
    Klotz, LO
    Schieke, SM
    Sies, H
    Holbrook, NJ
    [J]. BIOCHEMICAL JOURNAL, 2000, 352 : 219 - 225
  • [20] Klotz LO, 2001, MICRONUTRIENTS AND HEALTH: MOLECULAR BIOLOGICAL MECHANISMS, P184