Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas

被引：6
作者：
Nakayama, Toshiyuki
Yoshizaki, Ayumi
Naito, Shinji
Wen, Chun Yang
Alipov, Gabit
Yakata, Yuichi
Sekine, Ichiro
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Pathol, Nagasaki 8528523, Japan
[2] Natl Ureshino Med Ctr, Div Pathol, Res Lab, Saga 8430301, Japan
[3] Nanjing Univ, Dept Digest Dis, Nanjing Drum Tower Hosp, Sch Med, Nanjing 210008, Jiangsu Prov, Peoples R China
[4] Nagasaki Univ, Grad Sch Biomed Sci, Tissue & Histopathol Sect, Atom Bomb Dis Inst, Nagasaki 8528523, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 11期
关键词：
Ets-1; GISTs; leiomyoma; schwannoma; immunohistochemistry; risk category;
D O I：
10.3748/wjg.v12.i11.1743
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs. METHODS: Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital. RESULTS: Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs (96.4%), six leiomyomas (66.7%), and five schwannomas (83.3%) were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas (P < 0.005). However, there was no correlation between Ets-1 expression and clinical risk categories. CONCLUSION: Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas. (c) 2006 The WJG Press. All rights reserved.
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页码：1743 / 1746
页数：4
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