Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: A randomized, double-blind, placebo-controlled clinical trial

被引：68

作者：

Kolahdooz, M. ^{[1
]}

Nasri, S. ^{[1
]}

Modarres, S. Zadeh ^{[2
]}

Kianbakht, S. ^{[3
]}

Huseini, H. Fallah ^{[3
]}

机构：

[1] Payamenoor Univ, Dept Biol, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Mahdieh Hosp, Dept Obstet & Gynecol, Tehran, Iran

[3] ACECR, Inst Med Plants, Med Plants Res Ctr, Pharmacol & Appl Med Dept, Alborz, Karaj, Iran

来源：

PHYTOMEDICINE | 2014年 / 21卷 / 06期

关键词：

Nigella sativa seed oil; Male infertility; Abnormal semen quality; Traditional medicine; OXIDATIVE STRESS; SEMINAL PLASMA; DNA-DAMAGE; SUPPLEMENTATION; PARAMETERS;

D O I：

10.1016/j.phymed.2014.02.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In recent years, wide utilization of herbal drugs has encouraged scientists to determine their impressive effects on health. Since Nigella sativa L. seed (N. sativa) has many uses including infertility in traditional medicine, the effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men with abnormal semen quality are of interest. This study was conducted on Iranian infertile men with inclusion criteria of abnormal sperm morphology less than 30% or sperm counts below 20 x 10(6)/ml or type A and B motility less than 25% and 50% respectively. The patients in N. sativa oil group (n=34) received 2.5 ml N. sativa oil and placebo group (n=34) received 2.5 ml liquid paraffin two times a day orally for 2 months. At baseline and after 2 months, the sperm count, motility and morphology and semen volume, pH and round cells as primary outcomes were determined in both groups. Results showed that sperm count, motility and morphology and semen volume, pH and round cells were improved significantly in N. sativa oil treated group compared with placebo group after 2 months. It is concluded that daily intake of 5 ml N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：901 / 905

页数：5

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