Cadmium Effects on the Thyroid Gland

被引：64
作者：
Jancic, Snezana A. [1 ]
Stosic, Bojan Z. [2 ]
机构：
[1] Univ Kragujevac, Fac Med Sci, Inst Pathol, Dept Pathol, Kragujevac, Serbia
[2] Univ Kragujevac, Fac Med Sci, Kragujevac, Serbia
来源：
ENDOCRINE DISRUPTERS | 2014年 / 94卷
关键词：
IODOTHYRONINE 5-MONODEIODINASE ACTIVITY; CASPASE-INDEPENDENT APOPTOSIS; OXIDATIVE STRESS; GENE-EXPRESSION; PERMEABILITY TRANSITION; CELLULAR MECHANISMS; LIPID-PEROXIDATION; COMBINED EXPOSURE; SULFHYDRYL-GROUPS; EPITHELIAL-CELLS;
D O I：
10.1016/B978-0-12-800095-3.00014-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cadmium has been listed as one of the 126 priority pollutants and a category I carcinogen. Carcinogenic effects of cadmium on the lungs, testicles, and prostate are widely recognized, but there has been insufficient research on the effect of cadmium on the thyroid gland. Cadmium has the affinity to accumulate not only in the liver, kidneys, and pancreas but also in the thyroid gland. It has been established that cadmium blood concentration correlates positively with its accumulation in the thyroid gland. Women of fertile age have higher cadmium blood and urine concentrations than men. In spite of its redox inertia, cadmium brings about oxidative stress and damage to the tissue by indirect mechanisms. Mitochondria are considered to be the main intracellular targets for cadmium. Colloid cystic goiter, adenomatoid follicular hyperplasia with low-grade dysplasia and thyroglobulin hypo- and asecretion, and parafollicular cell diffuse and nodular hyperplasia and hypertrophy are often found in chronic cadmium toxicity.
引用
收藏
页码：391 / 425
页数：35
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