Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association. & Alzheimer's Drug Discovery Foundation

被引：27

作者：

Snyder, Heather M. ^{[1
]}

Ahles, Tim ^{[2
]}

Calderwood, Stuart ^{[3
]}

Carrillo, Maria C. ^{[1
]}

Chen, Honglei ^{[4
]}

Chang, Chung-Chou H. ^{[5
,6
,7
,8
]}

Craft, Suzanne ^{[9
]}

De Jager, Philip ^{[10
]}

Driver, Jane A. ^{[11
,12
,24
]}

Fillit, Howard ^{[13
]}

Knopmann, David ^{[14
]}

Lotze, Michael ^{[15
,16
,17
,24
]}

Tierney, Mary C. ^{[18
]}

Petanceska, Suzana ^{[19
]}

Saykin, Andrew ^{[20
]}

Seshadri, Sudha ^{[21
]}

Shineman, Diana ^{[13
]}

Ganguli, Mary ^{[22
,23
]}

机构：

[1] Alzheimers Assoc, Div Med & Sci Relat, Chicago, IL 60631 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, New York, NY USA

[3] Harvard Univ, Sch Med, Radiat Oncol, Boston, MA USA

[4] Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA

[5] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[6] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA

[7] Univ Pittsburgh, Sch Med, Dept Biostat, Pittsburgh, PA USA

[8] Univ Pittsburgh, Sch Med, Clin & Translat Sci, Pittsburgh, PA USA

[9] Wake Forest Univ Med, Dept Internal Med, Div Gerontol & Geriatr Med, Winston Salem, NC USA

[10] VA Boston HealthCare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA

[11] Brigham & Womens Hosp, Div Aging, 75 Francis St, Boston, MA 02115 USA

[12] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[13] Alzheimers Drug Discovery Fdn, Sci Affairs, New York, NY USA

[14] Mayo Clin, Dept Neurol, Rochester, MN USA

[15] Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA USA

[16] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA

[17] Univ Pittsburgh, Sch Med, Dept Bioengn, Pittsburgh, PA USA

[18] Sunnybrook Hlth Sci Ctr, Dept Family & Community Med, Toronto, ON, Canada

[19] NIA, Div Neurosci, NIH, Bethesda, MD 20892 USA

[20] Indiana Univ Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[21] Boston Univ, Sch Med, Div Neurol, Boston, MA 02118 USA

[22] Univ Pittsburgh, Sch Med, Psychiat Neurol & Epidemiol, Pittsburgh, PA USA

[23] Grad Sch Publ Hlth, Pittsburgh, PA USA

[24] Lion Biotechnol Inc, Tampa, FL USA

来源：

ALZHEIMERS & DEMENTIA | 2017年 / 13卷 / 03期

关键词：

Alzheimer's disease; Oncology; Cancer; Repurpose therapy; Epidemiology; Biological mechanisms; Genetics; AMYOTROPHIC-LATERAL-SCLEROSIS; ANDROGEN DEPRIVATION THERAPY; PARKINSON DISEASE; BREAST-CANCER; PROSTATE-CANCER; COGNITIVE FUNCTION; RISK; FUTURE; APOE; HETEROPLASMY;

D O I：

10.1016/j.jalz.2016.11.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases, including Alzheimer's disease. Understanding the intersection of the underlying biology for these two distinct families of diseases with one another may offer novel approaches to identify iiew therapeutic approaches and possible opportunities to repurpose existing drug candidates. The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop todelve into this discussion. Workshop participants outlined research focus areas, potential collaboratiOns, and partnerships for future action. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：267 / 273

页数：7

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