Non-coding RNA in thyroid cancer - Functions and mechanisms

被引：58

作者：

Cao, Jun ^{[1
]}

Zhang, Mengdi ^{[2
,3
]}

Zhang, Long ^{[2
,3
]}

Lou, Jianlin ^{[4
]}

Zhou, Fangfang ^{[5
,6
]}

Fang, Meiyu ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Dept Rare & Head & Neck Oncol, Zhejiang Canc Hosp,Chinese Acad Sci,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

[2] Zhejiang Univ, Life Sci Inst, MOE Lab Biosyst Homeostasis & Protect, Hangzhou 310058, Peoples R China

[3] Zhejiang Univ, Life Sci Inst, Innovat Ctr Cell Signaling Network, Hangzhou 310058, Peoples R China

[4] Univ Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Dept Head & Neck Surg, Chinese Acad Sci,Canc Hosp,Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

[5] Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China

[6] Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R China

来源：

CANCER LETTERS | 2021年 / 496卷

基金：

美国国家科学基金会;

关键词：

Thyroid cancer; Mechanism of action of noncoding RNA; Thyroid cancer treatment; CIRCULAR RNAS; PAPILLARY; CARCINOMA; ASSOCIATION; EXPRESSION; MICRORNAS; DIAGNOSIS; PROLIFERATION; PROGRESSION; BIOGENESIS;

D O I：

10.1016/j.canlet.2020.08.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thyroid cancer is the most common endocrine malignant tumor, and its incidence has increased significantly in the past few years. A growing number of noncoding RNAs (ncRNAs) have shown abnormal expression patterns in human thyroid cancer in recent studies. Depending on size, ncRNAs are usually subdivided into two categories: short ncRNAs and long ncRNAs (longer than 200 nucleotides). Short ncRNAs include microRNAs (miRNAs), PIWI-interacting RNAs, small nucleolar RNAs, and endogenous small interfering RNAs, which have been extensively studied due to their roles in developmental and tumor biology. Compared to that of short ncRNAs, the involvement of lncRNAs in human cancers, especially in thyroid cancer, is not as well studied. Here, we reviewed the roles and clinical significance of miRNAs, lncRNAs, and circular RNA in thyroid development, tumorigenesis, and metastasis to offer a new approach to thyroid cancer treatment.

引用

页码：117 / 126

页数：10

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