The ins and outs of MYC regulation by posttranslational mechanisms

被引：203

作者：

Vervoorts, Jorg ^{[1
]}

Luescher-Firzlaff, Juliane ^{[1
]}

Luescher, Bernhard ^{[1
]}

机构：

[1] Univ Aachen, Rhein Westfal TH Klinikum, Inst Biochem, Abt Biochem & Mol Biol, D-52057 Aachen, Germany

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2006年 / 281卷 / 46期

关键词：

D O I：

10.1074/jbc.R600017200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proteins of the MYC family are key regulators of cell behavior. MYC, originally identified as an oncoprotein, affects growth, proliferation, differentiation, and apoptosis of cells through its ability to regulate a significant number of genes. In addition MYC governs events associated with tumor progression, including genetic stability, migration, and angiogenesis. The pleiotropic activities attributed to MYC and their balanced control requires that the expression and function of MYC is tightly controlled. Indeed many different pathways and factors have been identified that impinge on MYC gene expression and protein function. In particular the protein is subject to different posttranslational modifications, including phosphorylation, ubiquitinylation, and acetylation. Here we discuss the latest developments regarding these modifications that control various aspects of MYC function, including its stability, the interaction with partner proteins, and the transcriptional potential.

引用

页码：34725 / 34729

页数：5

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