Preparation, characterization, and antitumor efficacy of biodegradable poly(lactic acid) methotrexate implantable films

被引：7
作者：
Singh, UV
Pandey, S
Umadevi, P
Udupa, N
机构：
[1] KASTURBA MED COLL & HOSP,COLL PHARMACEUT SCI,DEPT PHARMACEUT,MANIPAL 576119,KARNATAKA,INDIA
[2] KASTURBA MED COLL & HOSP,DEPT RADIOBIOL,MANIPAL,KARNATAKA,INDIA
来源：
DRUG DELIVERY | 1997年 / 4卷 / 02期
关键词：
biodegradable; drug release; films; methotrexate; poly(lactic acid);
D O I：
10.3109/10717549709051880
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Implantable methotrexate films using poly(D,L-lactic acid) and poly(L-lactic acid) (PLA) of different molecular weights were prepared. The in vitro drug release was dependent on the drug loading and molecular weight of the PLA. By blending these polymers in different ratios, the drug release could be controlled and modified. The antitumor efficacy in Sarcoma-180 tumor-bearing mice revealed that the implantable film was more efficacious than subcutaneous injection of plain methotrexate.
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收藏
页码：101 / 106
页数：6
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