Pathophysiology and Animal Models of Schizophrenia

被引：0

作者：

Dawe, Gavin S. ^{[1
]}

Hwang, Ern Huei Joel ^{[1
]}

Tan, Chay Hoon ^{[1
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Clin Res Ctr, Dept Pharmacol, Singapore 117597, Singapore

来源：

ANNALS ACADEMY OF MEDICINE SINGAPORE | 2009年 / 38卷 / 05期

基金：

英国医学研究理事会;

关键词：

Animal models; Pharmacotherapy; Schizophrenia; MOUSE MODEL; COGNITIVE DYSFUNCTION; HEALTHY-VOLUNTEERS; CHAKRAGATI MOUSE; GENES; DOPAMINE; DISC1; MICE; INHIBITION; KETAMINE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Animal models of schizophrenia are important for research aimed at developing improved pharmacotherapies. In particular, the cognitive deficits of schizophrenia remain largely refractory to current medications and there is a need for improved medications. We discuss the pathophysiology of schizophrenia and in particular the possible mechanisms underlying the cognitive deficits. We review the current animal models of schizophrenia and discuss the extent to which they meet the need for models reflecting the various domains of the symptomatology of schizophrenia, including positive symptoms, negative symptoms and cognitive symptoms.

引用

页码：425 / 430

页数：6

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