Synthesis and evaluation of phenoxy acetic acid derivatives as a anti-mycobacterial agents

被引：18
|
作者：
Yar, Mohammad Shahar [1 ]
Siddiqui, Anees Ahmad [1 ]
Ali, Mohamed Ashraf [1 ]
机构：
[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期
关键词：
pyrazoline; anti-mycobacterial; Mycobacterium tuberculosis;
D O I：
10.1016/j.bmcl.2006.06.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1-3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis H(37)Rv. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4571 / 4574
页数：4
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