Behavioral Changes in Rats Induced by a Dipeptidyl Peptidase IV Inhibitor Methionyl-2(S)-Cyanopyrrolidine: Experimental Model of Anxiety-Depression Disorder

被引：11

作者：

Krupina, N. A. ^{[1
]}

Kushnareva, E. Yu. ^{[1
]}

Khlebnikova, N. N. ^{[1
]}

Zolotov, N. N. ^{[2
]}

Kryzhanovskii, G. N. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Lab Gen Pathophysiol Nervous Syst, Moscow 109801, Russia

[2] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Lab Psychopharmacol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 147卷 / 03期

关键词：

dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine; anxiety; depression; model; rats; NEUROBIOLOGY;

D O I：

10.1007/s10517-009-0493-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Administration of a synthetic dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine (1 mg/kg) to rats during the early postnatal period was followed by the development of behavioral changes in young and adult animals. The degree of anxiety in the elevated plus maze increased in treated rats at the age of 1-2 months. Depressive behavior in the forced swimming test was typical of animals aging 2-3 months. Diazepam reduced the severity of anxiety in treated rats. Melipramine had a normalizing effect on swimming behavior. A novel prolyl endopeptidase inhibitor benzyloxycarbonylmethionyl-2(S)-cyanopyrrolidine had the antidepressant properties.

引用

页码：285 / 290

页数：6

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