Clinical trials of natural products as chemopreventive agents for prostate cancer

被引：48
作者：
Bemis, Debra L. [1 ]
Katz, Aaron E. [1 ]
Buttyan, Ralph [1 ]
机构：
[1] Columbia Univ, Med Ctr, Dept Urol, Coll Phys & Surg, New York, NY 10032 USA
来源：
EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2006年 / 15卷 / 10期
关键词：
chemoprevention; clinical trials; green tea catechins; isoflavones; lycopene; pomegranate phenolics; prostate cancer; selenium; vitamin D; vitamin E; Zyflamend (R);
D O I：
10.1517/13543784.15.10.1191
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Epidemiological research on prostate cancer risk in men throughout the world has identified significant correlations between dietary habits and prostate cancer occurrence. These studies served as a catalyst for exploration into the potential of dietary substances to act as chemopreventive agents against this disease, and include green tea catechins, lycopene, soy isoflavones, pomegranate phenolics, selenium, vitamins E and D, curcumin and resveratrol. Before these agents (in the dietary or purified forms) can be recommended as useful chemopreventive strategies for patients, their activity must be confirmed in rigorously designed clinical trials. This review discusses the preclinical and clinical data available for these dietary agents and describes relevant clinical trials currently being conducted.
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收藏
页码：1191 / 1200
页数：10
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