MicroRNA-130b promotes cell migration and invasion by targeting peroxisome proliferator-activated receptor gamma in human glioma

被引：15

作者：

Sheng, Xudong ^{[1
]}

Chen, Hu ^{[2
]}

Wang, Hui ^{[1
]}

Ding, Zhibin ^{[1
]}

Xu, Gangzhu ^{[1
]}

Zhang, Junfeng ^{[1
]}

Lu, Wenchao ^{[1
]}

Wu, Tao ^{[1
]}

Zhao, Ling ^{[3
]}

机构：

[1] Xian Med Coll, Affiliated Hosp 1, Dept Neurosurg, Xian 710077, Peoples R China

[2] Fourth Mil Med Univ, Tang Du Hosp, Dept Neurosurg, Xian 710038, Peoples R China

[3] Xian Med Coll, Affiliated Hosp 1, Dept Anesthesiol, Xian 710077, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 76卷

关键词：

MicroRNA-130b; Glioma; Peroxisome proliferator-activated receptor gamma; Invasion; Migration; EXPRESSION PROFILES; CANCER; TRANSITION; MIRNAS;

D O I：

10.1016/j.biopha.2015.10.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

MircroRNA-130b (miR-130b) has been recognized as an oncogenic miRNA and is implicated in the initiation and development of human cancers. Deregulation of miR-130b has been reported in several tumors. However, the clinical significance and its underlying role in human glioma are poorly explored. Herein, we found that the expression of miR-130b was significantly up-regulated in glioma tissues as compared with that in normal brain (NB) tissues. Clinical association analysis disclosed that high-expression of miR-130b was evidently associated with advanced tumor stage (grade III + IV) in glioma. Moreover, we disclosed that the high-expression of miR-130b conferred an obviously reduced survival of glioma patients. Multivariate Cox regression analysis showed that miR-130b expression was an independent prognostic indicator for glioma patients. Our gain-or loss-of-function studies showed that miR-130b promoted invasion and migration of glioma cells. Notably, miR-130b regulated peroxisome proliferator-activated receptor gamma (PPAR gamma) abundance and epithelial-mesenchymal transition (EMT) in glioma cells. Hereby, PPAR gamma was identified as a functional target of miR-130b in glioma. Furthermore, an inverse correlation between miR-130b and PPAR gamma expression was observed in glioma tissues. In conclusion, miR-130b is an independent prognostic biomarker for indicating survival of glioma patients and promotes glioma cell migration and invasion by targeting PPAR gamma. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：121 / 126

页数：6

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