Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity

被引：45

作者：

Mann, CLA ^{[1
]}

Davies, MB

Stevenson, VL

Leary, SM

Boggild, MD

Ko, CK

Jones, PW

Fryer, AA

Strange, RC

Thompson, AJ

Hawkins, CP

机构：

[1] N Staffordshire Hosp, Dept Neurol, Keele Multiple Sclerosis Res Grp, Stoke On Trent ST4 7LN, Staffs, England

[2] UCL, Inst Neurol, London WC1E 6BT, England

[3] Walton Ctr Neurol & Neurosurg, Liverpool, Merseyside, England

[4] Univ Keele, Dept Math, Keele ST5 5BG, Staffs, England

[5] Univ Keele, Postgrad Med Sch, Ctr Mol & Cell Med, Keele ST5 5BG, Staffs, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 129卷 / 1-2期

关键词：

multiple sclerosis; interleukin-1; interleukin-1 receptor antagonist; severity; linkage disequilibrium; SNP;

D O I：

10.1016/S0165-5728(02)00181-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1alpha (IL-1alpha), IL-1beta and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：197 / 204

页数：8

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